Inspiratory flow resistive loading improves respiratory muscle function and endurance capacity in recreational runners

Study using the PrO2 training protocol with recreational runners. Results suggest that training can improve endurance exercise performance in recreational runners by altering breathing mechanics, attenuating the oxygen cost, ventilation, HR, blood lactate and the perceptual response during constant workload exercise.

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Inspiratory resistive loading improves cycling capacity: a placebo controlled trial

Conclusion: Ten weeks of IMT attenuated the heart rate, ventilatory, and perceptual response to constant workload exercise, and improved the cycling time to exhaustion. Familiarisation was not a factor and the placebo effect was minimal.

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Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial

This a YouTube video summarizing the PrO2 component of the long covid trial performed in swansea.

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Effect of High-Intensity Inspiratory Muscle Training on Lung Volumes, Diaphragm Thickness, and Exercise Capacity in Subjects Who Are Healthy

The findings of this study suggest that high-intensity IMT with the PrO2 results in increased contracted diaphragm thickness and increased lung volumes and exercise capacity in people who are healthy.

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Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial

Methods: 281 adults (age 46.6±12.2 years; 88% female) recovering from self-reported COVID-19 (9.0±4.2 months post-acute infection) were randomised 4:1 to an 8-week IMT or a "usual care" waitlist control arm. Health-related quality-of-life and breathlessness questionnaires (King's Brief Interstitial Lung Disease (K-BILD) and Transition Dyspnoea Index (TDI)), respiratory muscle strength, and fitness (Chester Step Test) were assessed pre- and post-intervention. The primary end-point was K-BILD total score, with the K-BILD domains and TDI being key secondary outcomes.

Results: According to intention to treat, there was no difference between groups in K-BILD total score post-intervention (control: 59.5±12.4; IMT: 58.2±12.3; p<0.05) but IMT elicited clinically meaningful improvements in the K-BILD domains for breathlessness (control: 59.8±12.6; IMT: 62.2±16.2; p<0.05) and chest symptoms (control: 59.2±18.7; IMT: 64.5±18.2; p<0.05), along with clinically meaningful improvements in breathlessness according to TDI (control: 0.9±1.7 versus 2.0±2.0; p<0.05). IMT also improved respiratory muscle strength and estimated aerobic fitness.

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