Evidence-Based Respiratory Care.
Professional respiratory solutions for clinicians and patients. Remote monitoring, clinical assessments, and HIPAA-compliant protocols backed by 40+ studies.
Who Are You?
Select your role to see how PrO2 can support your clinical practice or recovery journey.
For Clinicians
Monitor patients remotely, manage protocols, track compliance, and access clinical data with HIPAA-compliant cloud platform.
Learn MoreFor Patients
Train under healthcare provider guidance to improve respiratory function, reduce symptoms, and enhance quality of life.
Learn MoreMonitor 1-1000+ Patients Remotely
Cloud-connected platform enabling real-time patient monitoring, protocol management, and data-driven insights from anywhere. HIPAA-compliant with CPT code support for billing.
Telehealth & Remote Patient Monitoring
Data-Driven Clinical Insights
Track MIP, MEP, SMIP, SMEP, and custom protocols with real-time data streaming. Identify trends, track progress, and make data-driven treatment decisions.
Customizable Treatment Protocols
Create and modify patient protocols remotely. Adjust training intensity, duration, and frequency based on individual patient progress and tolerance.
Patient Compliance Tracking
Monitor training adherence, session completion rates, and patient progress in real-time. Receive alerts for missed sessions or concerning trends.
CPT Code Support
Billing support for CPT codes 94200 (MIP/MEP), 94726 (pulmonary function), and remote monitoring codes. Export data for documentation and reimbursement.
HIPAA Compliant
Secure cloud platform with encrypted data transmission and storage. BAA available.
Multi-Patient Dashboard
Monitor all patients from a single interface. Sort, filter, and search by name, condition, or compliance.
Automated Alerts
Receive notifications for missed sessions, declining performance, or safety thresholds.
Research-Backed Clinical Applications
PrO2 respiratory muscle training is validated by peer-reviewed research across 15+ clinical conditions. Below are evidence-based applications supported by published studies using PrO2 devices.
COPD Assessment
PrO2's TIRE assessment measures (MIP, SMIP, ID) demonstrate excellent test-retest reliability and known-groups validity in COPD patients
Formiga MF, Campos MA, Cahalin LP (2018) - Reliability and Validity of the Test of Incremental Respiratory Endurance Measures in COPDCOPD Rehabilitation
PrO2 training has been successfully implemented in comprehensive COPD rehabilitation programs, with research demonstrating significant improvements in respiratory muscle strength and functional capacity
Vazquez-Gandullo E, Hidalgo-Molina A, et al. (2022) - Inspiratory Muscle Training in COPD as Part of a Pulmonary Rehabilitation Program ImplementationCOPD Management
A 2025 randomized controlled trial demonstrated that PrO2 TIRE training provides superior long-term efficacy and adherence compared to traditional threshold IMT in COPD patients
Dosbaba F, Hartman M, Formiga MF, Vlazna D, et al. (2025) - Long-Term Efficacy of Novel and Traditional Home-Based Remote Inspiratory Muscle Training in COPD: Randomized Controlled TrialCOPD Research
Doctoral research at University of Miami validated PrO2's comprehensive assessment capabilities and demonstrated superior training outcomes with TIRE methodology compared to traditional inspiratory muscle training in COPD patients
Formiga MF (2019) - Novel Measures of Inspiratory Muscle Function in COPD: Assessment and Training ImplicationsCOVID-19 Recovery
Eight weeks of unsupervised home-based PrO2 training improves inspiratory muscle strength, reduces dyspnea, and enhances quality of life in post-acute COVID-19 patients, with dose-dependent effects
Metcalfe RS, Swinton PA, Johannsen NM, et al. (2023) - Heterogeneous Treatment Effects After Inspiratory Muscle Training During Recovery from Post-Acute COVID-19COVID-19 Guidelines
Clinical guidelines recommend respiratory muscle screening and training interventions for COVID-19 patients. PrO2 provides both assessment and training capabilities for this application
Severin R, Franz CK, Farr E, et al. (2022) - The Effects of COVID-19 on Respiratory Muscle Performance: Making the Case for Respiratory Muscle Testing and TrainingLong-COVID
Research on Long-COVID recovery with PrO2 training shows that patients with more severe breathlessness and those beginning training 3+ months post-infection experience the greatest improvements in inspiratory muscle strength
Metcalfe RS, Swinton PA, et al. (2023) - Heterogeneous Treatment Effects Following Inspiratory Muscle Training During Recovery from Post-Acute COVID-19 SyndromeHeart Failure
Extensive research demonstrates inspiratory muscle training improves dyspnea, exercise tolerance, and functional status in heart failure patients. PrO2's full-breath resistance training provides these proven benefits with real-time feedback and remote monitoring
Cahalin LP, Arena R, Guazzi M, Myers J, et al. (2013) - Inspiratory Muscle Training in Heart Disease and Heart Failure: A Review of the Literature with a Focus on Method of Training and OutcomesCystic Fibrosis
Eight-week PrO2 training program significantly improves inspiratory muscle function, diaphragm thickness (structural adaptation), lung volumes, and exercise capacity in cystic fibrosis patients
Enright S, Chatham K, Ionescu AA, Unnithan VB, Shale DJ (2004) - Inspiratory Muscle Training Improves Lung Function and Exercise Capacity in Adults with Cystic FibrosisAsthma Management
Research demonstrates inspiratory muscle training decreases dyspnea, increases respiratory muscle strength, and improves exercise capacity in individuals with asthma. PrO2's full-breath resistance training provides this intervention with real-time feedback and progress tracking
Cahalin LP, Arena R (2015) - The Role of Inspiratory Muscle Training in the Management of Patients with Asthma and Exercise-Induced BronchoconstrictionPediatric Applications
Research demonstrates inspiratory muscle training improves respiratory muscle strength and endurance in pediatric populations with chronic lung disease. PrO2 provides age-appropriate protocols with visual biofeedback suitable for pediatric applications
Bhammar DM, Jones HN, Lang JE (2022) - Inspiratory Muscle Rehabilitation Training in the Pediatric Population: A Scoping ReviewNeuromuscular Diseases
Remote PrO2 training has demonstrated benefits even in rare neuromuscular diseases like VCP multisystem proteinopathy, improving respiratory function in patients with progressive muscle weakness
Halseth M, Mahoney R, Hsiou J, Jones HN, et al. (2024) - Remote Respiratory Resistance Training Improves Respiratory Function in VCP Multisystem ProteinopathyPersonalized Protocols
Research supports individualized training protocols over one-size-fits-all approaches for optimal patient outcomes. PrO2's customizable protocols and remote adjustability enable true personalization that traditional threshold devices cannot provide
Shei RJ, Paris HL, Sogard AS, Mickleborough TD (2022) - Time to Move Beyond a "One-Size Fits All" Approach to Inspiratory Muscle TrainingTIRE Methodology
PrO2's TIRE methodology has substantial potential to better direct and target inspiratory muscle training compared to traditional threshold loading methods
Cahalin LP, Arena R (2015) - Novel Methods of Inspiratory Muscle Training via the Test of Incremental Respiratory Endurance (TIRE)Smoking Impact Assessment
PrO2's TIRE assessment reveals sustained inspiratory pressure differences between former smokers and nonsmokers, indicating greater discriminatory ability than traditional MIP testing
Roach KE, Formiga MF, Vital I, Rao R, Cahalin LP (2018) - Inspiratory Muscle Performance of Former Smokers and Nonsmokers Using the Test of Incremental Respiratory Endurance (TIRE)Explore all 40+ peer-reviewed studies using PrO2 devices
View All ResearchAdvanced Assessment Capabilities
TIRE Methodology
Full-breath resisted training (not threshold). Target-based with real-time visual feedback. Clinically validated superior efficacy vs threshold devices.
Comprehensive Metrics
MIP, MEP, SMIP, SMEP, training volume, adherence, and trend analysis. Export data in CSV, PDF formats.
Evidence-Based Protocols
Pre-configured protocols for COPD, heart failure, COVID, asthma, and more. Or create custom protocols based on patient needs.
Ready to Enhance Patient Care?
Request clinician access to explore the PrO2 platform and see how remote respiratory monitoring can benefit your practice.
Train at Home, Monitored by Your Provider
PrO2 enables effective home-based respiratory muscle training under your healthcare provider's guidance. Strengthen your breathing muscles, reduce symptoms, and improve your quality of life.
How It Works
Provider Prescription
Your healthcare provider prescribes PrO2 training and sets up your personalized protocol.
Device Setup
Receive your PrO2 device and connect it to the mobile app via Bluetooth. Simple, guided setup.
Daily Training
Follow your prescribed training program. Visual feedback guides each breath. Typically 5-15 minutes per day.
Remote Monitoring
Your provider tracks your progress remotely and adjusts your protocol as needed.
Benefits for Patients
- Strengthen breathing muscles
- Reduce shortness of breath
- Improve exercise tolerance
- Enhance quality of life
- Train from home convenience
- Real-time visual feedback
- Track your own progress
- Stay connected with your provider
Conditions We Help Manage
PrO2 respiratory muscle training is research-validated for patients with various respiratory and cardiovascular conditions.
COPD
Long-COVID
Heart Failure
Asthma
Cystic Fibrosis
Neuromuscular
Post-Surgery
ICU Recovery
Talk to Your Healthcare Provider
Ask your doctor, respiratory therapist, or cardiologist if PrO2 respiratory muscle training is right for you.
Get Started Today
Professional-grade devices and subscription plans for healthcare providers and patients.